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Cockroaches are a common athropod in North America and a minor enemy in the Resident Evil horror game series. Many cockroaches in Raccoon City were infected with the T-virus. They appear in Resident Evil 2 and Resident Evil: The Darkside Chronicles.
The infected cockroaches show little-to-no change in their body or intelligence when infected with the virus.
- In the film Biohazard 4D-Executer, a cockroach was infected with the "t-Cameron virus," which allowed Dr. Cameron to take control of it. She controlled the creature up until she saw a rat, in which she passed the virus on. An infected cockroach also grew to a humanoid size and had large arms that had sharps talons and could impale victims within range, codenamed Reaper.