Trish, who bears a great resemblance to Dante’s deceased mother, Eva, is a creation of Mundus. As a result of her demonic nature, she possesses several supernatural abilities, such as superhuman strength and lightning-based powers. In the first game, she hires Dante to help stop Mundus' plan to conquer the human world, by opening a gate to the demon world on Mallet Island. Later in the game, Dante learns that she is a servant of Mundus, and that her resemblance to Eva was part of a plan to lure him to the island, so that Mundus' servants can kill him. However, she helps him defeat her master. In the game's epilogue, she and Dante are shown working together as partners out of the renamed "Devil Never Cry" office.
Trish does not appear as a part of Devil May Cry 2's storyline, presumably carrying out official demon eradication elsewhere. She can, however, be unlocked by beating the game on Hard Mode as Dante. Trish can be used in the entire game, equipped with Sparda, Luce & Ombra and Nightmare-γ as her weapons.
Outside of Devil May Cry, she has appeared exclusively in the PlayStation 2 version of Viewtiful Joe alongside Dante, and as a playable character in the PlayStation Portable game, Viewtiful Joe: Red Hot Rumble. She also appears in the anime and in the Devil May Cry Volume 2 novel, and is a playable character in Marvel vs. Capcom 3: Fate of Two Worlds and its update, Ultimate Marvel vs. Capcom 3.
In the anime, she has since gone solo, but reappears at intervals to work with Dante, who gave her an open invitation to come back at any time.
In Devil May Cry 4, Trish poses as Gloria, the only female Executive of the Holy Knights, in order to spy on the Order. She was able to quickly ascend the ranks by bringing the Sparda along withher, and giving it to Sanctus. Because of her looks and this suspiciously quick promotion, many members of the Order spread negative rumors about her; however, they also recognize her acrobatic and combat skills. Gloria's true identity as Trish is revealed after Nero fights Dante in Mission 10, and she later helps Dante by evacuating the town while he fights the Savior.
- Trish is voiced by Sarah Lafleur in Devil May Cry, Danielle Burgio in Devil May Cry 4, and in the anime she is voiced by Atsuko Tanaka and in the English dub by Luci Christian.